A long time ago I wrote about "trigger points" and why I didn't think they were in muscle.
Lately I've been working hard on a bunch of images of the neurovascular array around major joints. Also I've been working on a presentation I'm scheduled to give in a few weeks at the Massage Therapist Pain Conference in Vancouver.
I decided to make a slide that depicts some of the tubing array, and joins between them, and mechanical deformation, all at the same time.
Here is my effort:
Green is nerve, blue is vein, red is artery. (Ignore the blue bit in the top right corner - it's part of the slide format, not part of the image.)
Bear in mind that nerves and vessels can never exist very far apart from each other. Nerves need constant access to oxygen and glucose. Bear in mind that nerves don't have (according to current thinking) any lymph drainage. If any connector vessel were to become kinked or flattened by adverse mechanical tension, for a long time, like for example, by constantly sitting and never moving, the nerve, innervated by nociceptors, is likely to complain. This would be because of a high enough threshold stimulus of the mechano-, or chemo-, type (presumably thermo- would not be an issue).
The thing is, the physiological tubing of the body is attached all the way along. It twines and braids and twirls through the body, sliding through the same or very close "grommet holes" in stiff tissue layers to travel to the surface, into hypodermis.
By the time it reaches the cutis/subcutis layer, the vessels are small, but still, they remain attached to nerve which although is also smaller, has fewer fascicles and is therefore more vulnerable to compression and/or deformation.
Luckily, most of us have lots of padding. Still, if your hide is always pulled sideways somehow, always the same way, by some sort of contact with a surface, the tubing inside that layer will be pulled too - maybe it won't like it. Maybe the strain will be felt quite soon, or eventually, or be broadcast out along entire branches from related spinal cord segments. Sore spots will turn up before actual pain does, probably.